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Known as Gregory the Great, he was born into an affluent family in Central Italy., and was related to Felix III and Agapetus I. Being pretty much guaranteed a good career, his father chose the imperial civil service for him and was probably part of the reason he ended up as prefect of Rome in 572. Gregory, however, had a preference for the church.
After his father's death in 574, he turned his family's mansion on Caelian Hill into a monastery and became a monk.
In 578, Benedict I made him deacon and entrusted him with a few tasks, a tradition followed by many later popes. Gregory proved to be just as hardworking in his religious work as he was in his civil work. His only real failure was in terms of getting along with the patriarch of Constantinople.
After Pelagius' death, Gregory thought he'd be removed from papal service and had been preparing to move to an estate he had outside of Rome, where he'd set up another monastery.
Meanwhile, in Rome, there was still a prefect, but support for him was diminishing rapidly. The last known act of the senate in Rome happened during Gregory's pontificate, marking the end of a 1000+-year-old institution.